Mixed ligand catecholatobis diaminemonodithiocarbamato vanadium iv complexes were synthesized and characterized using ftir, uvvisible and 1 hnmr spectroscopic techniques. Mixed ligand complexes of bisphenylimine schiff base. We have also assessed the dna binding efficacy and mode of binding of both the complexes. The compounds obtained were characterised by analyses, infrared and visible spectral studies. Synthesis, characterization and biological activity of mixed ligand. B, which corresponds to four unpaired electrons typical of the d4 system. Synthesis, characterization and biological activity of mixed. Binary complexes, ternary complexes, mixed ligand, stability constant.
Weighed quantities of metal chelates were decomposed with a mixture of. This paper presents the synthesis and study of some new mixed ligands complexes containing anthranilic acid and amino acid lalanine ala with some metals. Chemical 110 1996 8994 mixed ligand complexes of chromiumiii and ironiii. Interaction of mixed ligand copperii complexes with ct dna and bsa. Theoretical composition curve remains toward left to the mixed ligand titration complex curve. In these complexes, histidine, and histidinemethylester act as bidentate ligands involving amino and imidazole. A series of new mixed ligand complexes based on 3,6bisimidazol1ylpyridazine.
Chiral mixed ligand cml metal complexes are synthesized by using. Pdf synthesis and characterization of the mixed ligand. Pdf synthesis and characterization of mixed ligand complexes. Synthesis of metal complexes of coii, niii, cuii and znii all the mixed ligand metal complexes were prepared by the same general procedure with stoichiometric amount of ligands and metal nitrate in a 1. Preparation, characterization, and antibacterial properties of mixed ligand complexes preparation, characterization, and antibacterial properties of mixed ligand complexes published on jul 4, 2015. A number of mixed metal complexes have been tested for antibacterial evaluation. Mixed ligand complexes of coii and niii containing. The mixed ligand complexes cr iii dpalcl and fe iii dpalh 2 o n cl where dpa dipicolinic acid, l ethylenediamine, 2,2bipyridine or 1,10phenanthroline, n 1 or 2 were synthesized and characterized by elemental analysis and spectral, magnetic, conductance and electrochemical studies. Pdf design of vanadium mixedligand complexes as potential anti. Synthesis and reactivity of some mixed ligand complexes of.
Preparation and characterization of new silicon mixed ligand complexes 1 z. Introduction comprehensive research has been carried out for the study of mixed ligand complexes and their importance in various biological processes 1, 2. Synthesis, characterization, biological studies, and. The metal content of the complexes were estimated by volumetric analysis. During recent years metal complexes of some no donor ligands have attracted considerable attention because of their greater antifungal and antibacterial activities than those of the parent ligands 4,5. Mixed ligand complexes of 1,1dithiolates and nitrogen donors. Transition metal ions, mixed ligands, copper complexes, dna binding. Furthermore, nta has also merged into the complexes skeletons for several purposes such as biotechnology, especially in the protein.
Reports on mixed ligand complexes of planar nili with nis2n2 chromophore are sparse. Figgis,introduction to ligand fields, wileyeastern 1976. Organic dibasic acid, malic acid plays role as primary ligand and heterocyclic amine bases play role as secondary ligands in the complexes. Formation constants of transition metal mixed ligand ternary complexes with biologically significant ligands dharmendra kumar sahu 1 and vijay shankar 2 1department of chemistry, university of allahabad, allahabad211002, u.
Stability constants of mixed ligand complexes of nickelii. Effect of primary ligand hydrophobicity on dna and protein binding and cleavage and anticancer activities. It has been found that many ternary complexes of some metals are significant for. Transition metal coordination complexes can be thought of in much the same way except that the transition metal is the acceptor and the molecules with lone pairs of. Formation constants of transition metal mixed ligand.
Pdf synthesis and characterization, of mixed ligand. Ironii, nickelii, copperii and zincii complexes of. Namely, the room temperature effective magnetic moments of the manganeseiii complexes with mixed ligands are in the range of 4. The merging and broadening of bands was found to be a common feature of. Synthesis and characterization of mixed ligand complexes 127 antibacterial study figure x ni, co, zn and cd complexes againststaphylococcusaureus and e. Samnani a, pabitra krishna bhattacharya a, pralhad a. The physical and elemental analysis of synthesized complexes shown in table1.
Naikwade3 1department of chemistry, milliya college beed m s 431122, india. The synthesis and structural characterization of mixed ligand complexes derived from 2,6pyridinedicarboxaldehydebisohydroxyphenylimine, 2,6pyridinedicarboxaldehydebisphydroxyphenylimine 1ry ligands and 2aminopyridne 2ry ligand are reported. Synthesis and characterization of mixed ligand complexes of coii ion with some n and s donor. Synthesis, characterization and antibacterial activities. Formation constants of transition metal mixed ligand ternary. In summary, we have synthesized and characterized three new mononuclear mixed ligand copperii complexes having tridentate reduced schiff bases and planar nndonor heterocyclic bases. Synthesis, characterization, and antibacterial studies of. All the complexes show nuclease activity in the presence of hydrogen peroxide in converting supercoiled puc19 dna to its nicked circular form. These complexes are generally referred to as donoracceptor complexes where ammonia would represent the donor and borane would represent the acceptor. Mixed metal complexes were prepared by the reaction of one metal complex with a different metal complex in molar ratio 1. The synthesis and characterization of mixed ligand complexes of coii and niii have been described. From the magnetic moments these complexes shows octahedral geometry. Synthesis, spectral characterization and antimicrobial activity of schiff bases and their mixed ligand metal complexes of coii, niii, cuii and znii. The former one is the shift of the stretching frequencies of the azomethine c n group of the transition metal complexes to lower frequencies and lie in the range of 16051611 cm.
The mixed ligand complexes cr iii dpalcl and fe iii dpalh 2o ncl where dpa dipicolinic acid, l ethylenediamine, 2,2bipyridine or 1,10phenanthroline, n 1 or 2 were synthesized and characterized by elemental analysis and spectral, magnetic, conductance and electrochemical studies. Mar 02, 2015 this paper describes the synthesis and characterization of mixed ligand complexes of coii, niii and cu ii with, phthalimide and heterocyclic amines. Ammoniaborane complexes are an example of this type of bonding figure 1. Equilibrium study and stability constants of mixed ligand. We have estimated from the elemental analysis results that. Physical measurements the molar conductance of the millimolar solutions of the complexes in dmf was measured using systronics. Studies on the mixed ligand complexes of coii, niii and.
Copperii complexes with the firstgeneration quinolone antibacterial agent norfloxacin containing a nitrogen donor heterocyclic ligand 2,2. Department of chemistry, university of allahabad, allahabad211002, u. Synthesis, spectral characterization and antimicrobial. Synthesis and characterization of mixed ligand complexes. Treatment of niopph3xcl2, nipph3xcl2 x cl, br, scn, no3 or niopph3icl2 with triphenylphosphine gave nipph32xcl. Synthesis, characterization and antibacterial evaluation of some mixedmetal mixedligand complexes mohammad n. The adsorption of co2 and ch4 in a mixedligand metal. Pdf synthesis and characterization of mixed ligand. The extraction of a metal with two chelating agents or with the participation of two neutral donors seems to be a. Each dirt sample is then compared to dirt found at the crime scene.
Stability constants of mixed ligand complexes of nickelii with adenine and some amino acids article pdf available in bioinorganic chemistry and applications 20155. While all the mixed ligand metal complexes are insoluble in organic solvents like diethylether, they are soluble in methanol, thf, and dmf. The elemental analysis, ir, uvvis and 1hnmr spectral analysis, colours, molar conductances and magnetic properties suggested that the complexes have formulation as mphimide2l24, where, m coii, niii and cuii. The zone of inhibition of the pefloxacinascorbic acid mixed ligand complexes. Synthesis and characterization of mixed ligand complexes of. Pdf synthesis and characterization of mixed ligand complexes of. In this regard, complexes of copper containing 1, 10phenanthroline phen as a ligand mixed with other types of ligands stirred great interests since they exhibit numerous biological activities such as antitumor, antibacterail zoroddu et al. Synthesis, characterization, of mixed ligand complexes of.
Melting points, elemental analysis, magnetic susceptibility measurements, ir, uv and 1hnmr spectral analysis were used in determining their physico. Synthesis and characterization of mixed ligand complexes of caffeine, adenine and thiocyanate with some transition metal ions sintesis dan pencirian kompleks ligan campuran kaffein, adenin dan tiosianat dengan beberapa ion logam peralihan shayma a. Yea min reza department of chemi stry, university of rajshahi, rajshahi 6205, bangladesh email. When the s values given in table 3 are examined, it can be seen that, in each of the mixed ligand complexes, the value is bigger than the statistical value of 0. Synthesis, characterization and antibacterial evaluation of. Synthesis, characterization, and fab mass spectral analysis article pdf available in journal of coordination chemistry 6218. Equilibrium study and stability constants of mixed ligand complexes of biomolecules and amino acids with metal ions by potentiometric method verma shalini, singh dharmveer, kumar rajendra, shukla brajesh kumar and krishna v. The possibility of formation of a mixture is ruled out from the obser. Pelagia research library measured on era uv160 spectrophotometrical. Since dorbitals of silicon tend to be rather diffused and of higher energy than its s and porbitals6, thus its complexes with donor ligands having silicon with.
A series of new mixedligand complexes based on 3,6bisimidazol1ylpyridazine. Pdf stability constants of mixed ligand complexes of. Mixed ligand complexes thesis writing i help to study. The mixed ligand complexes of composition, cl mna 2 a where anthranilic acid c 7 h 7 no 2 symbolized as ah and nicotinamidec 6 h 7 n 2 o symbolized. Chowdhury and jahowa islam department of chemistry, university of chittagong, chittagong4331, bangladesh. The present investigation is an extension of our earlier work on mixed ligand complexes8. Pdf the mixed ligand complexes of mnii, coii, niii, cuii, znii, cdii and hgii with alanine and 8hydroxyqinoline oxine were. Two new mixedligand coordination polymers based on multin. Amit kumar, rampal pandey, rakesh kumar gupta, kaushik ghosh, daya shankar pandey. Synthesis and characterization of mixed ligand complexes of coii and peiii ions with malonic acid and heterocyclic amines m saidullslam, md.
Metal ligand contributed by the chemistry student association at the university of texas at dallas main science idea for kids this activity is integrated into a crime scene investigation, in which dirt is found under each suspects shoe. The experimental data suggest that norfloxacin was coordinated to copperii through the carboxylato and. Synthesis, spectroscopic and in vitro antiproliferative studies. In the ir spectra of the mixed ligand complexes table 3 the bands. Alshama,a3 1 department of chemistry, college of education, university of mosul, mosul,iraq 2department of chemistry, college of agriculture, university of mosul, mosul,iraq. Mixed ligand complexes of feiii, coii, niii, and cuii. Mixed ligand metal complexes were prepared by refluxing the equimolar solutions of 2,4dinitro6pyridine2. During recent years metal complexes of some no donor ligands have attracted considerable attention because of their greater antifungal and antibacterial activities than. Pdf stability constants of mixed ligand complexes of nickel.
The analytical chemistry of mixed ligand complexes agent ha with neutral donors b hab, hab2, h2a2b, etc. Synthesis and characterisation of polymer supported mixed ligand complexes t he preparation of mixed ligand complexes in homogeneous conditions encounters difficultes due to the incomplete conversion of reactants. Mixed ligand complexes of znii and coii with cysteine, histidine, cysteinemethylester, and histidinemethylester have been synthesized and characterized by elemental analysis, conductivity, magnetic susceptibility measurements, and infrared,1h nmr, tga and fab mass spectra. Lokhande 1 1department of chemistry, university of mumbai, santacruz e, mumbai, india. Mixed ligand complexes of feiii, coii, niii, and cu. Design of novel oligomeric mixed ligand complexes mdpi. Nipph32x2 x cl, br or no3 on treatment with nitrosyl chloride in a benzene cyclohexane mixture as solvent, gave niopph3xcl2 x cl, br, no3. The ligand electrons are donated into d orbitals on the metal to form the new coordinate covalent bonds figure 2. Pdf mixed ligand complexes of znii and coii with cysteine, histidine, cysteinemethylester, and histidinemethylester have been synthesized and. Mixed ligand complexes thesis proposal abstract in chemistry, a complex, also called a coordination compound or metal complex, is a structure consisting of a central atom or molecule connected to surrounding atoms or molecules.
Synthesis, characterization and antibacterial evaluation. Mixed ligand complexes of transition metals are commonly found in biological systems. Transition metal complexes of 1,1dicyanoethylene2,2dithiolate and 1cyano1carboethoxy ethylene2,2dithiolate have received considerable attention of coordination chemistry since long because of their relative ease of formation of various types. The complexes were evaluated for their activity as catalysts for the epoxidation of olefins.
The usefulness of coordination metal complexes in cancer. However, elemental analysis and conductivity data reveal that in the obtained neutral mixed ligand complexes a univalent anion of ii and a molecule of are coordinated to the metal ion. Koshy b, sheo satish b a department of chemistry, faculty of science, m. It is supposed that in mixedligand complexes the ligand has localized. Furthermore, the concept of mixedligand synthesis has been applied to. Synthesis, characterization and dna binding study of mixed. Synthesis, characterization and biological activity of. Results and discussion mixed metal mixed ligand complexes were prepared by using water as the solvent. The formation constant of the mixed ligand complex is decisive in this aspect and when. Synthesis, characterization and microbial activity of chiral mixed.
Norfloxacin and ndonor mixedligand copperii complexes. Pdf coii and feii mixed ligand complexes of pefloxacin and. Studies on the mixed ligand complexes of coii, niii. The infrared spectra of these mixed ligand complexes in comparison with free cytidine and respective free. This shows that the formation of mixed ligand complexes is more prevalent than binary complexes. Synthesis, characterization and biological activity of mixed ligand coii complexes of schiff base 2amino4nitrophenolnsalicylidene with some amino acids ajay r. This paper describer the synthesis and characterization of several cuii complexes using 2,2 bipyridin as a primary ligand and ltyrosine, l tryptophan and l histidine as. Studies on the mixed ligand complexes of coii, niii and cu ii with phthalimide and heterocyclic amines. Sensitization of ruthenium nitrosyls to visible light via. The formation constant of the mixed ligand complex is.
Mixedligand complex formation of copper ii with some. This paper reports the synthesis, characterization, and antibacterial studies of mixed ligand dioxouraniumvi complexes prepared with 8hydroxyquinoline as a primary ligand and amino acids such as lthreonine, ltryptophan, and lisoleucine as secondary ligands. The resulting products were found to be solid crystalline complexes which have been. The studies exhibit that nickel hydrazine complex has. Synthesis, characterization and antibacterial activities of. Synthesis, characterization and biological studies on some. Physical properties and elemental analysis of mixed ligand complexes sr. Preparation and characterization of mnii transition. Separation of co2 from ch4 using mixedligand metal.